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Spyderco's Persistence knife is the smaller version of the Tenacious Model, another reliable descriptive of human nature. Spyderco have milled the black G-10 laminate handle with prolonged fatigue-free cutting in mind, as comfort in hand means easier use long-term.

Skeletonised steel liners tucked inside the handle increase the handle's rigidity and strength level without adding non-functional weight or bulkiness. The 8Cr13MoV stainless blade is a modified skinning-style, ground-flat.

Careful positioning of the oversized Spyderco Round Hole, relative to the location of the pivot, pre-set the hand in just the right spot for fumble-free one-hand blade open/close.